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Pipeline – BC 007

Pipeline and BC 007 Mode of Action

Our candidate BC 007 is a non-modified DNA aptamer that binds to and leads to the neutralization of autoantibodies that are directed against G-protein-coupled receptors (GPCR-AABs). E.g., BC 007 binds to ß1-adrenergic-receptor-autoantibodies as found in patients with Cardiomyopathy. BC 007 also binds to antibodies to other G-protein-coupled receptors which are found in in different autoimmune diseases as well as in Long-Covid patients.

BC 007 was successfully tested in a Phase-1 clinical trial. This study included a sub-group of subjects that are tested positive for GPCR-autoantibodies and which are otherwise healthy. The study design allowed for the proof that BC007 can neutralize GPCR-autoantibodies in humans. The full study design is published on clinicaltrials.gov

After successful completion of Phase 1/1b, we initiated a multi-center, randomised, controlled Phase 2 study in heart failure patients.

pipeline-nov-2016

Mode of Action

This video sequence demonstrates the mechanism of action of BC 007

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