A new paper is out summarizing the Phase 1 study with BC 007.
Read the full text HERE
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New Paper: The DNA-Based Drug BC 007 neutralizes agonistically acting autoantibodies directed against G protein–coupled receptors
Müller et al. (2019) The DNA-Based Drug BC 007 Neutralizes Agonistically Acting Autoantibodies Directed Against G Protein–Coupled Receptors -Successful Mode of Action Demonstrated in Clinical Phase 1 Trial. Chemistry Today March/April 37(2), 65-67
Read the abstract here and read full text article here
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New Article on BC007 in Atlas of Science
A new article on BC007 appeared in Atlas of Science.
https://atlasofscience.org/the-aptamer-bc007-for-the-treatment-of-functional-autoantibody-diseases-first-developed-for-patients-with-dilated-cardiomyopathy/
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New Paper: Performance and in-house validation of a bioassay for the determination of beta1-autoantibodies found in patients with cardiomyopathy (open access)
http://authors.elsevier.com/sd/article/S2405844016324392
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AUTOIMMUNITY REVIEWS 2017: Cardiomyopathy — An approach to the autoimmune background
European J of Pharmacology: Aptamer BC 007 – A broad spectrum neutralizer of pathogenic autoantibodies against G-protein-coupled receptors
Circulation 2000, eliminating Beta1-autoantibodies in heartfailure patients
The positive effects of elimination of Beta1-autoantibodies was first described in 2000
Fulltext can be downloaded here
Circulation-2000-Müller-385-91
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Circulation Research 2011;109: Aptamer Neutralization of Beta1-Adrenoceptor Autoantibodies Isolated From Patients With Cardiomyopathies (free full-text)
The aptamer can eliminate Beta1-Adrenoceptor Autoantibodies
Download free full text pdf:
Circulation Research-2011;109:986-992
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